Common Name(s): Bergenin,bergenin,isocoumarin c-glucoside,anti-inflammatory antiviral antioxidant
CAS Number: N/a
DESCRIPTION
What It Does: Inhibits xanthine oxidase to reduce uric acid and reactive oxygen superoxide generation, provides anti-inflammatory nf-kb pathway inhibition, and delivers antioxidant protection from the isocoumarin's catechol-related electron donation.
Why It's Used: Bergenin's xanthine oxidase inhibition provides a gout-adjacent anti-inflammatory mechanism โ reducing purine catabolism-derived reactive oxygen and uric acid crystal-mediated inflammation in skin through the same mechanism as allopurinol but from a natural isocoumarin scaffold.
How It Works: Bergenin catechol-like groups chelate the molybdenum cofactor of xanthine oxidase reducing superoxide radical oโโขโป generation from purine catabolism. simultaneously, bergenin inhibits nf-kb through iฮบb kinase interaction providing cytokine-level anti-inflammatory activity. the c-glucoside bond provides enzyme-resistant stability maintaining activity throughout shelf life.
Typically Found In: Anti-inflammatory,antioxidant
TECHNICAL DETAILS
Primary Category: Active ingredient โ antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%โ1%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Bergenin's c-glucosidic bond (carbon-carbon to the aglycone isocoumarin) resists glycosidase hydrolysis unlike o-glucosides โ providing exceptional formulation stability with no requirement for ph adjustment or enzymatic activation protection.
Last Verified: 2026-03-22
Primary Sources: Cosing database,bergenin isocoumarin xanthine oxidase anti-inflammatory review