Common Name(s): Barley sh-polypeptide-3,barley sh-polypeptide-3,barley-derived signal peptide or amino acid active,anti-aging bioactive
CAS Number: N/a
DESCRIPTION
What It Does: Stimulates collagen synthesis, inhibits mmp-mediated matrix degradation, or provides amino acid-specific skin metabolic support โ delivering measurable anti-aging benefit at ppm concentrations.
Why It's Used: Precision sequence-receptor pharmacology enables mechanism-based anti-aging claims โ defined amino acid sequence targeting specific receptors with quantifiable binding kinetics.
How It Works: Peptide receptor binding โ kinase cascade โ col1a1/col3a1 upregulation + mmp-1/mmp-3 downregulation. spps synthesis provides >98% sequence purity for reproducible receptor binding.
Typically Found In: Anti-aging serums,collagen products
TECHNICAL DETAILS
Primary Category: Active ingredient โ peptide
Secondary Functions: Collagen synthesis,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1โ5000 ppm
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating at recommended concentrations.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid
Avoid Combining With: Strong acids below ph 3.5; oxidising agents
SCIENTIFIC NOTE
Conjugated peptides provide dual mechanism: the peptide sequence provides receptor-mediated collagen synthesis stimulation while the aromatic/vitamin conjugate adds independent antioxidant or metabolic cofactor activity.
Last Verified: 2026-03-22
Primary Sources: Cosing database,barley sh-polypeptide-3 signal peptide anti-aging review