Common Name(s): Bakuchiol,(s)-bakuchiol
CAS Number: 10309-37-2
DESCRIPTION
What It Does: Provides retinol-equivalent anti-aging gene expression from a natural plant compound without retinol's limitations.
Why It's Used: The natural retinol alternative โ the first plant compound with rct evidence for equivalent anti-aging results to retinol with better safety and photostability.
How It Works: Bakuchiol activates rar beta and retinoid x receptors via allosteric binding mechanism. upregulates type i, iii, and iv collagen synthesis genes. downregulates mmp-1 and mmp-9. antioxidant via phenol radical scavenging. photostable โ stable to uv exposure unlike retinol.
Typically Found In: Natural anti-aging serums,pregnancy-safe retinol alternative,photostable anti-aging
TECHNICAL DETAILS
Primary Category: Active ingredient โ natural retinol alternative
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.5%โ2%
SOURCING & ETHICS
Vegan Status: Conditional - supplier confirmation required
Halal Status: Unverified - supplier confirmation required
Source Notes: Plant-derived extract or synthetic. [audit 2026-07-29 rev2: status downgraded on audit. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
The dhaliwal et al. (2019, british journal of dermatology) split-face rct directly compared 0.5% bakuchiol vs 0.5% retinol twice daily for 12 weeks โ both groups showed equivalent reduction in fine lines and wrinkles, but bakuchiol showed significantly less scaling, stinging, and burning. this is the strongest evidence that bakuchiol provides retinol-equivalent anti-aging with better tolerability.
Last Verified: 2026-03-12
Primary Sources: Cosing database,dhaliwal et al. bakuchiol vs retinol rct