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Common Name(s): Azeloyl diethyl salicylate,azeloyl diethyl salicylate,azelaic acid derivative,brightening anti-acne dual active

CAS Number: N/a

DESCRIPTION

What It Does: Provides azelaic acid's dual tyrosinase inhibition for brightening and anti-c. acnes activity through competitive enzyme inhibition, with additional functionality from the peptide or salicylate conjugate component.

Why It's Used: Azelaic acid is the only brightening active with concurrent anti-acne activity โ€” the dicarboxylic acid's competitive tyrosinase inhibition for brightening and mitochondrial oxidative phosphorylation disruption for c. acnes bacteriostatic activity provide dual-indication skin care from one molecule.

How It Works: Azelaic acid competitive tyrosinase inhibition: the c9 dicarboxylate mimics dopa substrate geometry competing at the cuยฒโบ active site (ic50 ~100 ฮผm). anti-c. acnes: the dicarboxylic acid disrupts c. acnes mitochondrial electron transport chain reducing atp synthesis below viability threshold. peptide/salicylate conjugate adds signal peptide anti-aging or bha exfoliant keratolytic activity.

Typically Found In: Brightening,anti-acne,anti-aging

TECHNICAL DETAILS

Primary Category: Active ingredient โ€“ antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%โ€“2%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Azelaic acid derivative formulation advantage: the conjugate form improves sc penetration of free azelaic acid (highly hydrophilic, logp -0.5) through the lipid ester/amide modification raising logp to 2-4 for improved sc delivery.

Last Verified: 2026-03-22

Primary Sources: Cosing database,azeloyl diethyl salicylate azelaic acid derivative brightening review