Common Name(s): L-asparagine,2-amino-3-carbamoylpropanoic acid

CAS Number: 70-47-3

DESCRIPTION

What It Does: Provides skin conditioning and supports n-linked protein glycosylation for ecm structural glycoproteins.

Why It's Used: Used in skin conditioning and ecm-supporting formulations.

How It Works: Primary n-linked glycosylation acceptor (asn-x-ser/thr sequon). glycosylation of collagen, proteoglycans, and fibronectin at asparagine residues critically affects their water retention and structural functions.

Typically Found In: Skin conditioning products,ecm support formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – amino acid

Secondary Functions: Glycoprotein n-glycosylation,ecm support

Application Areas:

Typical Concentration Range: 0.5%–3%

SOURCING & ETHICS

Vegan Status: Conditional - supplier confirmation required

Halal Status: Unverified - supplier confirmation required

Source Notes: Fermentation-derived or synthetic. natural skin component. [audit 2026-07-29 rev2: status downgraded on audit. determination requires shariah-panel sign-off.]

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; endogenous skin molecule.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. natural skin nmf component. ewg score: 1.

Works Well With: Hyaluronic acid,ceramides,peptides,other amino acids

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

N-linked glycosylation at asparagine residues is essential for proper folding, secretion, and function of nearly all extracellular matrix proteins. age-related changes in glycosylation patterns affect ecm protein function and water binding capacity.

Last Verified: 2026-03-12

Primary Sources: Cosing database,cir safety assessment