Common Name(s): Brahmic acid,centella active

CAS Number: 464-92-6

DESCRIPTION

What It Does: Stimulates normal wound healing collagen synthesis while preventing excessive fibrosis and hypertrophic scar formation.

Why It's Used: Unique anti-fibrotic wound healing ingredient – stimulates collagen i and iii while reducing excessive tgf-β-driven fibrosis, making it ideal for preventing hypertrophic scars.

How It Works: Stimulates col1a1/col3a1 transcription in normal fibroblasts while inhibiting tgf-β-induced myofibroblast differentiation that drives hypertrophic scar formation. also inhibits nf-kb for anti-inflammatory activity.

Typically Found In: Scar prevention products,post-procedure recovery,wound healing

TECHNICAL DETAILS

Primary Category: Active ingredient – soothing / anti-inflammatory

Secondary Functions: Anti-fibrotic,scar prevention,collagen regulation

Application Areas:

Typical Concentration Range: 0.01%–1%

SOURCING & ETHICS

Vegan Status: Yes – from centella asiatica

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; ideal for reactive and sensitive skin.

Safe for Sensitive Skin: Yes – particularly recommended for sensitive skin

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,panthenol,allantoin,hyaluronic acid,centella asiatica

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

The paradox of asiatic acid is its ability to both stimulate collagen synthesis (anti-aging) and prevent fibrosis (anti-scarring) from the same compound. this selective effect occurs because asiatic acid stimulates normal fibroblast collagen synthesis while specifically inhibiting tgf-β1-driven myofibroblast transformation – the cell type responsible for excessive scar tissue.

Last Verified: 2026-03-12

Primary Sources: Cosing database,maquart et al. asiatic acid study