Common Name(s): Eyeseryl,ac-beta-ala-his-ser-his

CAS Number: 820959-17-9

DESCRIPTION

What It Does: Reduces periorbital puffiness and edema by limiting hyaluronan accumulation and improving vascular integrity.

Why It's Used: Targeted eye peptide for comprehensive under-eye treatment addressing puffiness, dark circles, and loss of firmness through multiple complementary mechanisms.

How It Works: Inhibits hyaluronan-protein cross-linking that causes excessive water retention (edema) under eyes. also reduces vascular permeability and improves lymphatic drainage. anti-glycation activity reduces skin stiffness.

Typically Found In: Eye creams,under-eye serums,anti-puffiness products

TECHNICAL DETAILS

Primary Category: Active ingredient – eyeseryl eye peptide

Secondary Functions: Anti-edema,dark circle reduction,eye firmness

Application Areas:

Typical Concentration Range: 50–500 ppm

SOURCING & ETHICS

Vegan Status: Yes – synthetically produced

Halal Status: Yes

Source Notes: Spps synthesis. commercially available as eyeseryl (lipotec).

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Exceptional safety profile. ewg score: 1.

Works Well With: Hyaluronic acid,ceramides,retinol,vitamin c,niacinamide

Avoid Combining With: Avoid mixing with high-concentration ahas at same ph (may hydrolyze peptide bonds)

SCIENTIFIC NOTE

Under-eye puffiness is driven by hyaluronan accumulation (water binding) and impaired lymphatic drainage. eyeseryl's inhibition of ha-protein crosslinking reduces the osmotic water-trapping capacity of the extracellular matrix, providing a mechanistically unique anti-puffiness approach.

Last Verified: Cosing database,lipotec eyeseryl technical data,clinical study journal of cosmetic dermatology

Primary Sources: 2026-03-12