Common Name(s): Procapil peptide component,hair follicle stem cell peptide
CAS Number: 827306-88-7
DESCRIPTION
What It Does: Provides wnt/beta-catenin hair follicle stem cell activation for follicle regeneration.
Why It's Used: Wnt-activating hair peptide โ acetyl tetrapeptide-3 activates the fundamental molecular switch initiating each new hair growth cycle (wnt/beta-catenin), providing stem cell-level follicle regeneration beyond simple follicle stimulation.
How It Works: Wnt/beta-catenin activation in hair follicle bulge stem cells โ stem cell proliferation and differentiation. anti-dht signalling interference preventing stem cell exhaustion. combined with apigenin and biotinoyl tripeptide-1 as procapil system.
Typically Found In: Anti-alopecia serums,procapil products
TECHNICAL DETAILS
Primary Category: Active ingredient โ signal peptide
Secondary Functions: Collagen stimulation,skin firming,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.0001%โ0.005%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Synthetically produced by solid-phase peptide synthesis (spps). may be palmitoylated for stability.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; suitable for all skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Exceptional safety profile. ewg score: 1.
Works Well With: Hyaluronic acid,ceramides,retinol,vitamin c,niacinamide
Avoid Combining With: Avoid mixing with high-concentration ahas at same ph (may hydrolyze peptide bonds)
SCIENTIFIC NOTE
Wnt/beta-catenin is the master regulator of hair follicle stem cell activation โ every hair growth cycle begins with wnt signal activation of the bulge stem cell compartment. acetyl tetrapeptide-3 targets this fundamental initiating step, providing the most upstream possible intervention in the hair growth cycle.
Last Verified: Cosing database,sederma procapil technical data
Primary Sources: 2026-03-12