Common Name(s): Thymulen 4,thymopoietin fragment

CAS Number: N/a

DESCRIPTION

What It Does: Provides thymulin-like skin immunity restoration and collagen stimulation.

Why It's Used: Immunoaging anti-aging peptide — targets the decline of skin immune function with aging (thymic involution leads to reduced skin immunity) for immune-restoration anti-aging approach unavailable from conventional collagen peptides.

How It Works: Thymopoietin-derived sequence activates thymulin-like receptors on skin immune cells. restores langerhans cell and skin t-cell function declining with age. stimulates collagen synthesis via immunocyte-fibroblast paracrine signalling.

Typically Found In: Mature skin anti-aging products,immune-targeting anti-aging

TECHNICAL DETAILS

Primary Category: Active ingredient – signal peptide

Secondary Functions: Collagen stimulation,skin firming,anti-aging

Application Areas:

Typical Concentration Range: 0.0001%–0.05%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Synthetically produced by solid-phase peptide synthesis (spps). may be palmitoylated for stability.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Exceptional safety profile. ewg score: 1.

Works Well With: Hyaluronic acid,ceramides,retinol,vitamin c,niacinamide

Avoid Combining With: Avoid mixing with high-concentration ahas at same ph (may hydrolyze peptide bonds)

SCIENTIFIC NOTE

Skin immune function decline (immunosenescence) contributes to impaired wound healing and increased skin cancer risk with aging — by targeting skin-specific immunity restoration rather than just ecm synthesis, thymulen 4 addresses an anti-aging mechanism largely neglected by conventional collagen-targeting approaches.

Last Verified: Cosing database,vial peptide technical data

Primary Sources: 2026-03-12