Common Name(s): Acetyl sh-tripeptide-1 amide,acetyl sh-tripeptide-1 amide,cosmetic functional ingredient,established active
CAS Number: N/a
DESCRIPTION
What It Does: Provides the characteristic cosmetic function of its ingredient class through molecular chemistry at recommended use concentration.
Why It's Used: Acetyl sh-tripeptide-1 amide is selected for the gly-his-lys signal sequence โ the ghk copper-chelating tripeptide activates tgf-beta collagen synthesis, mmp-2 wound repair, and timp-1 anti-aging gene expression at low ฮผg/ml concentrations, making it the most studied collagen signal peptide in cosmetic science.
How It Works: Functional groups interact with formulation components and skin through h-bonding, ionic association, surface adsorption, or receptor activity as appropriate to the molecular class.
Typically Found In: Cosmetic formulations
TECHNICAL DETAILS
Primary Category: Active ingredient โ cosmetic active
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%โ10%
SOURCING & ETHICS
Vegan Status: Conditional
Halal Status: Yes
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1โ2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Safety documented in cosing at standard formulation concentrations.
Last Verified: Cosing database,acetyl sh-tripeptide-1 amide technical review
Primary Sources: 2026-03-22