Common Name(s): Snap-8,acetyl octapeptide-8,extended argireline

CAS Number: 868844-74-0

DESCRIPTION

What It Does: Provides enhanced expression line reduction through superior snare complex interference vs argireline.

Why It's Used: Premium alternative to argireline for more potent expression line reduction with extended snap-25 sequence mimicry.

How It Works: 8-amino acid snap-25 sequence provides more complete competitive inhibition of snare complex formation than argireline's 6-amino acid sequence, resulting in greater reduction of acetylcholine vesicle fusion and neuromuscular transmission.

Typically Found In: Premium anti-wrinkle serums,expression line treatments

TECHNICAL DETAILS

Primary Category: Active ingredient – snap-8 neuromodulator

Secondary Functions: Enhanced snare inhibition,superior expression line reduction

Application Areas:

Typical Concentration Range: 100–1000 ppm

SOURCING & ETHICS

Vegan Status: Yes – synthetically produced

Halal Status: Yes

Source Notes: Synthesized by spps. commercially available as snap-8 (lipotec).

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Exceptional safety profile. ewg score: 1.

Works Well With: Hyaluronic acid,ceramides,retinol,moisturizers

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

The additional 2 amino acids in snap-8 vs argireline provide a more complete consensus sequence for snap-25 receptor site competition. in vitro studies confirm superior snare complex disruption. clinical comparisons show greater wrinkle depth reduction at equivalent concentrations.

Last Verified: Cosing database,lipotec snap-8 technical data

Primary Sources: 2026-03-12