Common Name(s): Abietoyl dipeptide-22,abietoyl dipeptide-22,lipid-conjugated or aromatic-modified peptide,advanced anti-aging signal peptide

CAS Number: N/a

DESCRIPTION

What It Does: Delivers signal peptide bioactivity to deeper sc layers through the lipid anchor's sc lipid-phase integration — providing receptor-mediated collagen synthesis stimulation at dermal targets accessible only to lipophilic peptide conjugates.

Why It's Used: Lipid conjugation is the essential enabling technology for peptide skin care — without sc penetration enhancement, most signal peptides remain on the surface and cannot reach their fibroblast receptor targets in the dermis.

How It Works: The fatty acid or aromatic anchor (logp contribution ~+3 per c16 chain) partitions the peptide into sc lipid bilayers. lateral diffusion through the sc lipid matrix carries the peptide toward the dermis where tissue enzymes cleave the lipid, releasing the active peptide sequence for receptor binding. spps synthesis provides >98% purity for reliable receptor pharmacology.

Typically Found In: Premium anti-aging serums,collagen products

TECHNICAL DETAILS

Primary Category: Active ingredient – peptide

Secondary Functions: Collagen synthesis,anti-aging

Application Areas:

Typical Concentration Range: 1–5000 ppm

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating at recommended concentrations.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid

Avoid Combining With: Strong acids below ph 3.5; oxidising agents

SCIENTIFIC NOTE

Lipid anchor selection impacts delivery profile: longer chain (c18) → higher logp, slower sc transit, deeper penetration; shorter chain (c12) → faster release, shallower delivery. formulator selects based on target receptor tissue depth.

Last Verified: Cosing database,abietoyl dipeptide-22 lipid-conjugated peptide anti-aging review

Primary Sources: 2026-03-22