Back to Ingredient Dictionary

MELITTIN

Description

Melittin is a powerful bioactive peptide derived from bee venom, specifically from the European honey bee (Apis mellifera). This compound comprises 26 amino acids and is the primary active component in bee venom, accounting for approximately 50% of its dry weight. Melittin exhibits a unique amphipathic structure, allowing it to interact with cell membranes and exert various biological effects.

In skincare formulations, melittin is gaining attention for its potential anti-inflammatory, antimicrobial, and anti-aging properties. It has been shown to stimulate collagen production and improve skin elasticity, potentially reducing the appearance of fine lines and wrinkles. Melittin also demonstrates the ability to inhibit matrix metalloproteinases (MMPs), enzymes responsible for breaking down collagen and elastin in the skin.

However, the use of melittin in skincare products requires careful consideration due to its potent nature. In high concentrations, it can cause skin irritation and allergic reactions, particularly in individuals with bee venom allergies. Formulators must balance its efficacy with safety concerns, typically using low concentrations and combining it with soothing ingredients to mitigate potential side effects. Clinical studies are ongoing to further elucidate melittin's long-term effects and optimal usage in skincare applications.